pentobarbital decreases amounts of toremifene by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. CYP3A4 inducers maximize price of toremifene metabolism, decreasing the steady-state concentration in serum.pentobarbital will reduce the extent or outcome of tofacitinib by influencing hepatic/intestinal enzyme CYP3A4 metaboli